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目的:探讨糖尿病视网膜病变患者血清炎症因子、脂肪因子及氧化应激指标的水平变化。方法:选取我院收治的2型糖尿病患者130例,分为糖尿病无视网膜病变组(NDR)41例、非增殖期视网膜病变组(NPDR)44例和增殖期视网膜病变组(PDR)45例,另选取同期于我院体检的健康志愿者40名作为对照组(NC),检测各组的血清IL-6、TNF-α、hs-CRP、瘦素、脂联素、MDA和SOD水平。结果:各组IL-6、TNF-α、hs-CRP水平比较差异有统计学意义(P<0.05);PDR组均显著高于NC组、NDR组、NPDR组,NPDR组均显著高于NC组、NDR组,NDR组均显著高于NC组,差异均有统计学意义(P<0.05)。各组瘦素、脂联素水平比较,差异有统计学意义(P<0.05),PDR组瘦素高于NC组、NDR组、NPDR组,脂联素低于NC组、NDR组、NPDR组,NPDR组瘦素高于NC组、NDR组,脂联素低于NC组、NDR组,NDR组瘦素高于,脂联素低于NC组,差异均有统计学意义(P<0.05)。各组MDA、SOD水平比较差异有统计学意义(P<0.05),PDR组MDA高于NC组、NDR组、NPDR组,SOD低于NC组、NDR组、NPDR组,NPDR组MDA高于NC组、NDR组,SOD低于NC组、NDR组,NDR组MDA高于NC组,SOD低于NC组,差异均有统计学意义(P<0.05)。结论:糖尿病视网膜病变与炎症因子、脂肪因子及氧化应激指标具有密切关联。
Objective: To investigate the changes of serum inflammatory factors, adipokines and oxidative stress in patients with diabetic retinopathy. Methods: A total of 130 type 2 diabetic patients admitted to our hospital were divided into diabetic retinopathy (NDR) group (n = 41), nonproliferative retinopathy group (n = 44) and proliferative diabetic retinopathy group (n = 45) Another 40 healthy volunteers were selected as control group (NC). The levels of IL-6, TNF-α, hs-CRP, leptin, adiponectin, MDA and SOD in each group were measured. Results: The levels of IL-6, TNF-α and hs-CRP in each group were significantly different (P <0.05); PDR group was significantly higher than NC group, NDR group, NPDR group and NPDR group were significantly higher than NC Group, NDR group and NDR group were significantly higher than NC group, the difference was statistically significant (P <0.05). The levels of leptin and adiponectin in each group were significantly different (P <0.05). The levels of leptin in PDR group were higher than those in NC group, NDR group, NPDR group and adiponectin group The levels of leptin in NPDR group were higher than those in NC group, NDR group and adiponectin group were lower than those in NC group. The levels of leptin in NDR group and NDR group were lower than those in NC group (P <0.05) . The levels of MDA and SOD in each group were significantly different (P <0.05), the MDA in PDR group was higher than that in NC group, NDR group, NPDR group, SOD was lower than NC group, NDR group, NPDR group and NPDR group were higher than NC group NDR group and SOD group were lower than those in NC group. MDA in NDR group and NDR group were higher than NC group and SOD was lower than NC group (P <0.05). Conclusion: Diabetic retinopathy is closely related to inflammatory factors, adipokines and oxidative stress.