关于新生儿高胆红素血症的病因,一般认为,主要是与母子血型不合(Rh溶血症及ABO溶血症),和感染所致的溶血症有关,其次,未成熟儿、新生儿呼吸窘迫综合征、内出血、遗传性红细胞形态异常等亦有一定的关系。1960年Smith等首先在新加坡报告13例由红细胞G-6-PD缺陷(以下简称G-6-PD缺陷)所致的新生儿核黄疸,其中有12例是华籍新生儿。以后相继在我国香港和台湾、马来亚、希腊、意大利、非洲黑人、西班牙犹太人、印度、班图、泰国等地报告同样的病例。国内文献尚未见有关报道。我科近年来发现在住院的167例新生儿高胆红素血症病 About neonatal hyperbilirubinemia etiology, is generally believed that, mainly with the mother and child blood group incompatibility (Rh hemolytic disease and ABO hemolytic disease), and hemolytic disease caused by infection, and secondly, immature infants, neonatal respiratory distress Syndrome, internal bleeding, hereditary erythrocyte morphology abnormalities also have a certain relationship. In 1960, Smith et al first reported 13 cases of neonatal kernicterus caused by G-6-PD erythrocytes (hereinafter referred to as G-6-PD defect) in Singapore, of which 12 were Chinese newborns. Later in succession, the same cases were reported in Hong Kong, Taiwan, Malaya, Greece, Italy, Negroes, Spanish Jews, India, Bantu and Thailand. Domestic literature has not seen the relevant reports. In recent years, our department found 167 newborns with hyperbilirubinemia in hospital