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我院(北京医学院)通过对白胡椒治疗癫痫的民间验方的研究,证明白胡椒有效成分为胡椒碱(piper-ine),在此基础上人工合成了抗痫灵。抗痫灵结构近似胡椒碱,动物实验研究证明:它对多种动物实验性癫痫有效,如在小于 TD_(20)剂量下,对大白鼠和小白鼠电休克惊厥、代四氮惊厥、士的宁惊厥。印防己毒惊厥和大鼠听源性发作、脑室内注射筒箭毒碱、谷氨酸钠引起的发作,均有不同程度的对抗作用,是一种广谱的抗惊厥药,作用性质和苯妥英钠近似(均能对抗电休克惊厥),但不完全相同:后者大剂量时可引起动物惊厥,抗痫灵则否。
Our hospital (Beijing Medical College) through the white pepper treatment of epilepsy folk prescription studies to prove that the active ingredient of white pepper piperine (piper-ine), on this basis, synthetic anti-epilepsy Ling. The structure of anti-epileptic Ling similar to piperine, animal experimental studies have shown that: it is effective in experimental epilepsy in a variety of animals, such as less than the TD_ (20) dose, electroconvulsive seizures in rats and mice, tetrazolium convulsions, Ning convulsions. It is a broad spectrum of anticonvulsant drugs, phenytoin and phenytoin, which have different degrees of antagonism against seizures and amphoteric seizures in rats, intracerebroventricular injection of myostatin and sodium glutamate. Sodium approximation (both against electroconvulsive convulsions), but not exactly the same: the latter can cause high doses of animal convulsions, anti-epileptic Ling is not.