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目的 :研究 p5 3、PCNA、C- erb B- 2、nm2 3等多项癌基因表达与食管癌切除术后患者生存期的关系。方法 :按术后 2年内死亡 (对照组 )和长期生存 5年以上 (生存组 )分组 ,随机随访食管癌切除术后 6 3例患者的手术标本 ,用免疫组织化学技术进行多项癌基因检测。结果 :生存组和对照组中的癌基因 p5 3、PCNA、C- erb B- 2表达均较强烈 ,但与患者生存期长短无关。生存组的 nm2 3阳性表达率 87.1% (2 7/ 31)明显高于对照组 2 8.1% (9/ 32 ) ,两组比较 (P<0 .0 1)有统计学意义。结论 :nm2 3的强烈表达与食管癌患者生存期明显相关 ,说明机体对食管癌的转移和复发有较强的抑制作用 ,对食管癌手术后患者的预后有一定的临床意义。
OBJECTIVE: To study the relationship between the expression of many oncogenes p5 3, PCNA, C-erb B- 2 and nm23 and the survival of esophageal cancer patients after resection. Methods: A total of 63 patients who underwent resection of esophageal cancer were randomly divided into two groups according to their death (control group) and long-term survival of more than 5 years (survival group). Multiple oncogenes were detected by immunohistochemistry . Results: The expressions of oncogene p5 3, PCNA and C erb B-2 in the survival group and the control group were all strongly expressed but not related to the patient’s survival. The positive expression rate of nm23 in the survival group was 87.1% (27/31), which was significantly higher than that in the control group (8.11%, 9/32). There was significant difference between the two groups (P <0.01). Conclusion: The strong expression of nm23 in esophageal cancer patients with strong expression was significantly related to the survival of esophageal cancer metastasis and recurrence have a strong inhibitory effect on the prognosis of patients with esophageal cancer surgery has some clinical significance.