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本文对36例实体恶性肿瘤病人外周血嗜中性粒细胞的EA-RFC进行了测定,并与58例正常人对比,测得受试肿瘤病人的EA-RFC(58.28%)明显低于正常人(80.86%,P<0.01)。同时观察到肿瘤病人血清及3种不同的实体瘤组织提取液中存在花环形成抑制因子,初步认为此抑制因子产生于肿瘤组织,再释放到外周血中,抑制PMN的Fc受体功能,表现为PMN的EA-RFC明显降低。被抑的PMN经不同时间培养,其EA-RFC又见回升(P<0.01),说明受抑的Fc受体功能可得到不同程度恢复,因而推测其抑制作用在一定条件下是可逆的。
In this paper, 36 cases of solid malignant tumor patients with peripheral blood neutrophil EA-RFC was measured and compared with 58 normal subjects, the measured tumor patients EA-RFC (58.28%) was significantly lower than normal (80.86%, P <0.01). At the same time, it was observed that the anther of the tumor patient’s serum and the three different solid tumor tissue extracts contained the inhibitor of rosette formation. The inhibitor was initially thought to be produced in the tumor tissue and then released into the peripheral blood to inhibit the Fc receptor function of the PMN. EA-RFC for PMN is significantly reduced. Suppressed PMNs were cultured at different times and their EA-RFCs were also up-regulated (P <0.01), indicating that suppressed Fc receptor function could be restored to some extent. Therefore, it is presumed that its inhibitory effect is reversible under certain conditions.