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本文报道的方法是将固相萃取(SPE)过程和液相色谱-质谱/质谱(LC-MS/MS)运行同步进行,当前一样品正在分析时,下一样品在萃取,这样,实现了全自动在线SPE-LC-MS/MS测定,大大提高了工作效率。该方法已用于给猎犬同时口服或静注10种候选药物进行药代动力学筛选。分析方法 将血浆样
The approach reported here is to synchronize the solid-phase extraction (SPE) process and liquid chromatography-mass spectrometry / mass spectrometry (LC-MS / MS) operation with the current sample being analyzed and the next sample being extracted Automatic on-line SPE-LC-MS / MS measurement, greatly improving work efficiency. The method has been used to give dogs the same time oral or intravenous injection of 10 candidate drugs for pharmacokinetic screening. Analytical methods will be plasma-like