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大鼠42只按体重均分 7组,每组 6只,分别给以ACMA、ACMB和 ADM小鼠急性LD50的1/10及1/60剂量,另一组为生理盐水对照组。连续腹腔给药 7天后,检查大鼠的外周血象和骨髓有核细胞的变化。 1/10 LD50剂量组的ACMA和ADM外周血液内白细胞数显著下降,且ACMA组中性分叶核白细胞百分率显著降低。两剂量组的骨髓有核细胞计数明显的减少,其中 ACMA 3mg/kg组的骨髓增生程度为 2例低下、4例极度低下,粒系细胞的抑制尤为显著。而等毒剂量的ACMB组对大鼠外周血象与骨髓有核细胞与NS对照组比较均无显著差异。 因此,虽然ACMB对小鼠的急性毒性比ACMA大一倍多,与ADM相当,但以等毒剂量比较它们对大鼠骨髓造血功能的影响则以ACMB为最轻。
Forty-two rats were equally divided into 7 groups with 6 rats in each group, which were administered 1/10 and 1/60 of the acute LD50 of ACMA, ACMB and ADM mice, respectively. The other group was saline control group. After continuous intraperitoneal administration for 7 days, the changes of peripheral blood and bone marrow nucleated cells in rats were examined. 1/10 LD50 dose group of ACMA and ADM peripheral blood leukocyte count decreased significantly, and ACMA group of neutral lobular white blood cell percentage was significantly lower. Two-dose group of bone marrow nucleated cell count was significantly reduced, including ACMA 3mg / kg group of bone marrow hyperplasia was 2 cases low, 4 cases of extremely low, particularly inhibited granulosa cells. However, there was no significant difference in isobaric doses of ACMB group between peripheral blood cells of rats and bone marrow nucleated cells and NS control group. Thus, although acute toxicity of ACMB in mice is more than double that of ACMA, comparable to that of ADM, their effects on hematopoietic function in rat bone marrow at isochronal doses are the least for ACMB.