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目的 探讨经常性的有氧运动对特发性中枢性性早熟 (ICPP)女孩生长和促生长素轴功能的影响。方法 9例ICPP女孩单纯运动治疗 (5 1± 1 6 )个月 ,比较其运动治疗前后生长、发育以及GH -IGF - 1轴的功能。结果 ICPP女孩单纯运动治疗后在性腺不抑制的情况下生长速度显著加快 ,身高年龄与骨龄的比值显著增加 ,空腹血清骨钙素、胰岛素样生长因子 1(IGF - 1)水平显著增加 ,胰岛素样生长因子结合蛋白 3(IGFBP - 3)水平及IGFBP - 3/IGF - 1比值显著降低。结论 经常性的有氧运动能作为促进ICPP女孩实现生长和成熟正平衡、改善成年身高的有效辅助干预手段。
Objective To investigate the effects of regular aerobic exercise on the growth and the function of somatotropin in girls with idiopathic central precocious puberty (ICPP). Methods 9 cases of ICPP girls were treated with simple exercise (51 ± 16 months). Their growth, development and GH-IGF-1 axis function were compared before and after exercise therapy. Results The growth rate of ICPP girls was significantly increased after simple exercise therapy, and the ratio of height to bone age was significantly increased. The fasting serum osteocalcin and insulin - like growth factor 1 (IGF - 1) levels were significantly increased. Insulin - like The level of IGFBP - 3 and the ratio of IGFBP - 3 / IGF - 1 were significantly decreased. CONCLUSIONS: Regular aerobic exercises can be used as an effective supplementary intervention to promote ICPP girls to achieve balanced growth and maturity and to improve their height.