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目的 :探讨鼻咽癌组织放疗后病理改变及其临床意义。方法 :采用TdT酶介导的生物素化dutp缺口末端标记技术和HE染色 ,检测 30例鼻咽癌组织放疗前后的细胞凋亡率 ,并比较放疗前后的组织病理改变。结果 :鼻咽癌组织放疗后的细胞凋亡率明显高于放疗前 ;放疗后的癌细胞分化趋好 ,但到放疗中期时凋亡率有所下降。结论 :鼻咽癌放疗一方面可加速癌细胞的凋亡 ,另一方面可能促使增殖的癌细胞朝分化好的方向发展 ,从而达到治疗目的
Objective: To investigate the pathological changes of nasopharyngeal carcinoma after radiotherapy and its clinical significance. Methods: TdT-mediated biotinylated dutp nick end labeling technique and HE staining were used to detect the apoptosis rate of 30 nasopharyngeal carcinoma tissues before and after radiotherapy. The histopathological changes were compared before and after radiotherapy. Results: The apoptosis rate of nasopharyngeal carcinoma after radiotherapy was significantly higher than that before radiotherapy. The differentiation of cancer cells after radiotherapy was better, but the apoptosis rate decreased to the middle of radiotherapy. Conclusion: Radiotherapy of nasopharyngeal carcinoma can accelerate the apoptosis of cancer cells on the one hand, and on the other hand, it may promote the proliferation of cancer cells in a well-differentiated direction for therapeutic purposes