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目的:分析妇科消炎方与硝呋太尔制霉素对老年霉菌性阴道炎患者血清C反应蛋白(CRP)和氧化应激产物及其临床疗效。方法:选取2014年3月—2015年11月间收治的老年霉菌性阴道炎患者84例,采用奇偶分组法将其分为对照组和观察组,每组42例;对照组患者给予硝呋太尔制霉素治疗,观察组患者则在此基础上加用中药妇科消炎方治疗;比较两组患者治疗前后血清炎性因子与氧化应激产物水平以及总有效率。结果:治疗后两组患者的TNF-α、CRP、IL-6、IL-8、SOD、NO、MDA以及ET-1水平均优于治疗前(P<0.05);但观察组患者的改善情况明显优于对照组(P<0.05),总有效率高于对照组(P<0.05)。结论:采用中药妇科消炎方与硝呋太尔制霉素治疗老年霉菌性阴道炎患者的临床效果较好,可有效改善患者血清炎性因子与氧化应激产物水平。
OBJECTIVE: To analyze the serum C-reactive protein (CRP) and oxidative stress products of gynecological anti-inflammatory prescription and nifuratel nystatin in elderly patients with fungal vaginitis and its clinical efficacy. Methods: Eighty-four elderly patients with fungal vaginitis were selected from March 2014 to November 2015. The patients were divided into control group and observation group with 42 cases in each group by the method of parity grouping. The patients in the control group were treated with nifurate Treatment of nystatin, observation group patients are based on the use of Chinese medicine gynecological anti-inflammatory side treatment; compared two groups of patients before and after treatment serum inflammatory cytokines and oxidative stress product levels and the total effective rate. Results: After treatment, the levels of TNF-α, CRP, IL-6, IL-8, SOD, NO, MDA and ET-1 in both groups were better than those before treatment (P <0.05) Obviously better than the control group (P <0.05), and the total effective rate was higher than that of the control group (P <0.05). Conclusion: The clinical effect of the Chinese medicine Gynecologic Anti-inflammatory Decoction and Nifuratel Nifedipine in the treatment of elderly patients with fungal vaginitis is better, which can effectively improve the levels of serum inflammatory cytokines and oxidative stress products.