T细胞活化过程的研究是现代免疫学研究的一个重要领域.随着对T细胞活化过程认识的逐步深入,发现越来越多T细胞表面分子参与这一过程.CD28分子就是近几年来所发现的一种参与T细胞活化的辅助分子.本文就其分布、结构特征、天然配体、信号传导通路和效应功能等方面的研究进展作一综述. T cell activation process is an important area of ​​modern immunology research.With the gradual understanding of T cell activation process, more and more T cell surface molecules are found to be involved in this process.CD28 molecule is found in recent years As a helper molecule involved in the activation of T cells.In this paper, the research progress of its distribution, structural features, natural ligands, signal transduction pathways and effector functions are reviewed.