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目的观察米非司酮联合甲氨蝶呤(MTX)治疗异位妊娠的疗效。方法将确诊为异位妊娠并有保守治疗指征的患者分为甲、乙2组各20例。甲组采用米非司酮方案,乙组采用米非司酮配伍甲氨蝶呤方案。比较2组的治愈率、-βHCG下降速度及不良反应发生情况。结果 2组的治愈率、用药后血-βHCG下降速度比较差异有统计学意义(P<0.05和0.01),2组不良反应发生情况差异无统计学意义。结论同等条件下米非司酮联合甲氨蝶呤治疗异位妊娠的疗效优于单纯应用米非司酮,且成功率高,减少患者手术创伤,大大地提高了妇女的生育率。
Objective To observe the efficacy of mifepristone combined with methotrexate (MTX) in the treatment of ectopic pregnancy. Methods The patients diagnosed as ectopic pregnancy with conservative treatment indications were divided into two groups, arm A and arm B, 20 cases each. Group A with mifepristone program, Group B with mifepristone with methotrexate program. Compare the cure rate of two groups, -βHCG decline rate and adverse reactions. Results The cure rate of the two groups was significantly lower than that of the control group (P <0.05 and 0.01) after treatment. There was no significant difference in adverse reactions between the two groups. Conclusions The efficacy of mifepristone and methotrexate in the treatment of ectopic pregnancy under the same conditions is better than that of mifepristone alone, and the success rate is high, reducing the surgical trauma and greatly increasing the fertility rate of women.