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作者以往在小白鼠足垫感染模型中发现抗甲状腺药甲巯咪唑(他巴唑),丙硫氧嘧啶及另外2种有抗甲状腺作用的药物丁氨苯硫脲,5—正—庚—2—氧(代)—4—噻唑烷酮(5-n-heptyl-2-oxo-4-thiazolidinone简称噻唑烷酮)能抑制麻风菌繁殖单纯用~(131)碘治疗则无类似抑制作用。小白鼠同时给甲状腺制剂和甲巯咪唑能完全抵消后者的抗甲状腺作用而仍能抑制麻风菌的繁殖,但单纯投与甲状腺制剂也能抑制麻风菌繁殖,故尚不能确定甲巯咪唑抗微生物作用与抗甲状腺作用的相互关系。为此,进行以下研究。小白鼠足垫接种10~(3·7)条麻风菌,治疗组自当天起喂以含药饲料,试验者即前述4种药物,每种药物有2种浓度,相差10倍。对照组在接种144天后足垫平均菌数已达10~6条。治疗组在接种145～152天后自足垫回收菌计数,同时测定血浆中蛋白结合碘(PBI)和甲状腺素(T_4)含量,
In the past, we found anti-thyroid drugs methimazole (methimazole), propylthiouracil and two other drugs that have antithyroid effects, such as butachfur, 5-n-heptan-2 (5-n-heptyl-2-oxo-4-thiazolidinone for short) could inhibit the reproduction of leprosy without the similar inhibition by 131I alone. Thyroid preparations and thiamethoxam could completely counteract the anti-thyroid effect of the latter and inhibit the reproduction of leprosy. However, administration of thyroid preparations alone could inhibit the growth of leprosy, so the antimicrobial effect of methimazole could not be determined And anti-thyroid effect of the interrelationship. To this end, the following study. The mouse pad was inoculated with 10 ~ (3.7) leprosy, and the treatment group was given the medicated feed from the same day. The test subjects were the above 4 drugs, each with 2 concentrations, a difference of 10 times. The average number of footpad in control group reached 10 ~ 6 after 144 days inoculation. In the treatment group, the count of recovered bacteria was recovered from the foot pad 145 to 152 days after inoculation, and the content of protein-bound iodine (PBI) and thyroid hormone (T 4)