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目的探讨RAGE阻断剂FPS-ZM1对异氟醚麻醉诱发老龄大鼠认知功能障碍的影响。方法将老龄大鼠60只,随机分为4组(n=15):NS+O2组、NS+ISO组、FPS-ZM1+ISO组及FPS-ZM1+O2组。NS+O2组及NS+ISO组,侧脑室注射无菌0.9%氯化钠溶液10μL,FPS—ZM1+ISO及FPS-ZM1+O2组,侧脑室注射FPS—ZM110μL(5g/L)。侧脑室注射后24h,NS+O2及FPS-ZM1+O2组吸入含有30%氧气的空氧混合气体4h,FPS-ZM1+ISO及FPS-ZM1+IS