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黑龙江省肿瘤医院自1980年1月～1990年l月经手术治疗确诊为视网膜母细胞瘤共53例,均行手术切除和术后放射治疗,术后放疗剂量在40GY/4周,观察随访者25例,其中有3例发生第2恶性肿瘤,报告如下: 3例病人主要临床资料见附表 视网膜母细胞瘤是危及生命较严重的眼科疾病,且为多中心起源,预后多不良。本文3例视网膜母细胞瘤手术加放疗后存活者发生了第2种恶性肿瘤。 视网膜母细胞瘤术后放疗诱发第2种恶性肿瘤常见的是成骨肉瘤及皮肤肿瘤,发生的潜伏期不一,可能与环境和遗传等因素有关。由于放疗剂量过大,较易发生在放疗区内,
Tumor Hospital of Heilongjiang Province from January 1980 to January 1990 was diagnosed with retinoblastoma by surgery in 53 cases, both underwent surgical resection and postoperative radiotherapy, postoperative radiotherapy dose of 40GY / 4 weeks, the observed follow-up 25 Cases, of which 3 cases of the occurrence of the second malignant tumor, the report is as follows: The main clinical data of 3 patients, see attached Schedule Retinoblastoma is endangering life more serious eye diseases, and is a multicentric origin, the prognosis is poor. This article 3 cases of retinoblastoma surgery plus radiotherapy after the occurrence of the second malignant tumor. The second type of malignant tumor induced by postoperative radiotherapy of retinoblastoma is osteosarcoma and skin tumor. The incubation period varies depending on factors such as environment and genetics. As the radiation dose is too large, more prone to radiotherapy area,