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目的:探讨妊娠和子代结局与助孕方式的相关性。方法:回顾性统计分析2002.03～2008.07期间本中心所有ARTs助孕并妊娠的周期。按IUI、IVF-ET等助孕方式分组,比较妊娠、子代情况。结果:临床妊娠683个周期,新生儿701例,出生缺陷15例,出生缺陷率各种助孕方式间无统计学差异。早期流产率ICSI方式高于常规IVF方式;常规IVF的宫外孕率高于ICSI;出生多胎率IVF-ET组高于IUI组,P均<0.05。IVF-ET与IUI比、常规IVF与ICSI比,多胎比单胎均有更高的剖宫产率,P<0.05或P<0.01。出生婴儿男女比例为1∶1.03,单胎比多胎有更高的男孩比例,P<0.05。IVF-ET与IUI比,多胎比单胎早产率高,P<0.05或P<0.01。结论:ICSI和FET操作未明显增加新生儿出生缺陷风险,但其子代遗传风险可能偏高;常规IVF比ICSI有更高的宫外孕和剖宫产风险;IVF-ET产科风险高于IUI。
OBJECTIVE: To investigate the correlation between pregnancy and offspring outcomes and pregnancy-promoting patterns. METHODS: Retrospective statistical analysis of all ARTs assisted pregnancies and pregnancies during the period from March 2002 to July 2008 was conducted. By IUI, IVF-ET and other methods of pregnancy by group, compare pregnancy, offspring situation. Results: 683 cycles of clinical pregnancy, 701 cases of newborns, birth defects in 15 cases, birth defects rate of various methods of pregnancy between no significant difference. The rate of early abortion was higher in ICSI than that in routine IVF. The IVF in routine IVF was higher than that in ICSI. The multiple birth rate in IVF-ET group was higher than that in IUI group (P <0.05). The ratio of IVF-ET to IUI was higher for conventional IVF vs ICSI than for singletons (P <0.05 or P <0.01). The ratio of male to female at birth was 1: 1.03, with a higher proportion of singletons than multiple births (P <0.05). The rate of IVF-ET to IUI was higher for multiple births than for single births, P <0.05 or P <0.01. CONCLUSIONS: ICSI and FET manipulation did not significantly increase the risk of neonatal birth defects, but their offspring may be at higher genetic risk. Conventional IVF has a higher risk of ectopic pregnancy and cesarean delivery than ICSI. The IVF-ET obstetric risk is higher than that of IUI.