【摘 要】
:
Alzheimer’s disease (AD) is the most common progressive neurodegenerative disorder of aging. The characteristic features of AD begin as mild cognitive dysfunctions, which gradually progress to the fatal delirium through a total loss of cognition and execu
【机 构】
:
Department of Chemistry,University of Miami,Coral Gables,FL,USA
论文部分内容阅读
Alzheimer’s disease (AD) is the most common progressive neurodegenerative disorder of aging. The characteristic features of AD begin as mild cognitive dysfunctions, which gradually progress to the fatal delirium through a total loss of cognition and executive motor functions (Pimplikar et al., 2010). Three decades later from now, more than 100 million people will suffer from AD worldwide by making it the most expensive disease (Prince et al., 2013; Bloom, 2014). The major pathological hallmarks of the AD is the extracellular amyloid-beta (Aβ) plaques deposition and the intracellular neurofibrillary tangle-aggregation of hyperphosphorylated tau-proteins. Despite the fact that Aβ and tau-phosphorylation is the primary etiology for the AD, the recent concern developed on anti-amyloid mechanisms, such as cholinergic dysfunction and reactive oxygen species (ROS) generation. The current most prevalent clinical arena is, treating amyloid or non-amyloid hypothesis individually. However, the intercorrelated nature of amyloid and non-amyloid hypothesis governs the need of the intervention of combined diagnostic approaches.
其他文献
We have recently established a mouse model of focal stroke under dual antiplatelet therapy (DAPT) to study tissue plasminogen activator (tPA)-associated hemorrhagic transformation. The purpose of this short perspective is to discuss the rationale for esta
Brain angiotensin Ⅱ (ANG Ⅱ) as a pleiotropic player: Mental disorders have been commonly associated with an imbalance in many neurotransmitter systems, such as dopamine, glutamate, and gamma-aminobutyric acid. Considering the complexity of brain functioni
Atorvastatin has been shown to be a safe and effective non-surgical treatment option for patients with chronic subdural hematoma.However, treatment with atorvastatin is not effective in some patients, who must undergo further surgical treatment. Dexametha
Autophagy is a process of cellular degradation for the removal of damaged components and eventual recycling of the resulting molecules that help to the maintenance of cellular homeostasis. Through this pathway, proteins with relatively long half-life and
Neuroinflammation in the brain is thought related to the emergence of various psychoses, although the identifying regional significance, the involvement of immune-cells and lymphocytic activity, and ways for the therapeutic recovery are under the effort o
Retinal neurodegenerative diseases like age-related macular degeneration, glaucoma, diabetic retinopathy or retinitis pigmentosa are the most frequent causes of incurable low vision and blindness worldwide. It had been estimated that the prevalence of the
Tar DNA-binding protein 43 (TDP-43, encoded by the gene TARDBP) neuronal and glial inclusions have unified amyotrophic lateral sclerosis (ALS, ~97% of all cases), a fatal adult onset motor neuron disease characterized by the selective loss of upper and lo
Perceiving pitch is a central function of the human auditory system; congenital amusia is a disorder of pitch perception. The underlying neural mechanisms of congenital amusia have been actively discussed. However, little attention has been paid to the ch
Metabolic syndrome (MetS) might be defined as the simultaneous accumulation of several functional changes that frequently occur in adults over 60 years of age (Gomez et al., 2018).
Transcranial direct current stimulation (tDCS) has been reportedly beneficial for differentneurodegenerative disorders. tDCS has been reported as a potential adjunctive or alternative treatment for auditory verbal hallucination (AVH). This study aims to r