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采用去肾上腺大鼠模型试验显示,双调素1.00g/kg和地塞米松0.50mg/kg灌胃给药均可增加去肾上腺SD大鼠肝糖原含量;地塞米松可明显升高正常大鼠肝糖原,但其分别加用双调素1.00,0.50,0.25g/kg各组与正常对照组间的差别无显著性意义(P>0.05)。采用二甲苯致炎法和皮下棉球肉芽肿致炎法试验显示,双调素1.00,0.50、0.25g/kg及其加用和单用地塞米松1.00mg/kg灌胃给药均可抑制小鼠耳廓肿胀度、减轻小鼠皮下肉芽肿的干重,但地塞米松单用与加用双调素各组间的差别无显著性意义(P>0.05)。结果说明双调素具有双向调节肝糖原和抗急、慢性炎症的作用,而不影响糖皮质激素的抗炎作用
The de-adrenal rat model test showed that bifixune 1.00g/kg and dexamethasone 0.50mg/kg can increase the hepatic glycogen content in de-adrenal SD rats by intragastric administration; dexamethasone can be significantly increased. Normal rat hepatic glycogen, but its addition of bifunctional 1.00, 0.50, 0.25 g/kg each group and the normal control group had no significant difference (P> 0.05). Xylene induced inflammation and subcutaneous granuloma granulomatous inflammation test showed that bifunctional 1.00, 0.50, 0.25 g/kg plus and dexamethasone alone 1.00mg/kg gavage The administration of dexamethasone inhibited the ear swelling of mice and reduced the dry weight of subcutaneous granuloma of mice, but there was no significant difference between dexamethasone alone and bimodal administration (P>0.05). . The results suggest that bipropyne has the function of bidirectional regulation of hepatic glycogen and resistance to acute and chronic inflammation without affecting the anti-inflammatory effects of glucocorticoids