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目的探讨脓毒症患者血清淀粉酶升高的临床意义及其与预后的关系。方法80例ICU脓毒症(APACHEⅡ评分>30分)患者,根据血清淀粉酶水平分为血清淀粉酶升高组(Ⅰ组)和正常组(Ⅱ组),比较两组血白细胞总数、低血压发生率、心律失常发生率、机械通气使用率、住院时间及病死率的变化。结果80例脓毒症患者中,18例(22.5%)血清淀粉酶升高,胰腺损伤(血清淀粉酶≥400 U/L)发生率为11.3%。血清淀粉酶升高组低血压发生率、心律失常发生率、机械通气使用率、ICU住院时间、病死率明显高于血清淀粉酶正常组。血清淀粉酶水平愈高,预后愈差。血清淀粉酶≥400 U/L,病死率明显增高(P<0.01)。结论对脓毒症患者应注意血清淀粉酶的变化,血清淀粉酶可能是反映病情变化、判定预后的一个重要指标。
Objective To investigate the clinical significance of elevated serum amylase in patients with sepsis and its relationship with prognosis. Methods Eighty patients with ICU sepsis (APACHEⅡ score> 30) were divided into serum amylase (group Ⅰ) and normal group (group Ⅱ) according to serum amylase level. The total number of white blood cells, hypotension Incidence, rate of arrhythmia, rate of use of mechanical ventilation, length of stay, and mortality. Results Serum amylase increased in 18 (22.5%) of 80 sepsis patients, and the incidence of pancreatic injury (serum amylase ≥ 400 U / L) was 11.3%. Serum amylase increased the incidence of hypotension, arrhythmia incidence, the use of mechanical ventilation, ICU length of stay, mortality was significantly higher than the serum amylase normal group. The higher the serum amylase level, the worse the prognosis. Serum amylase ≥400 U / L, mortality was significantly higher (P <0.01). Conclusion Serum amylase should be noticed in patients with sepsis. Serum amylase may be an important indicator to reflect the change of disease and prognosis.