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目的观察雷公藤多苷片配厄贝沙坦对糖尿病肾病患者临床症状、尿蛋白、血浆白蛋白、血肌酐、血白细胞的影响。方法 64例患者随机分为观察组和治疗组,每组32例。两组皆适用降糖方案加厄贝沙坦进行治疗,观察组在此基础上加用雷公藤多苷片。以30d为1个疗程,连用3个疗程,观察两组变化。结果观察组治疗后较治疗前Upro、Scr、ALB、WBC及疗效明显改善,差异有统计学意义(P<0.01),观察组与治疗组的Upro、Scr、ALB、WBC比较明显改善,差异有统计学意义(P<0.01)。结论雷公藤多苷片配合厄贝沙坦治疗糖尿病肾病效显著,可明显减少蛋白尿,缓解症状,提高血白蛋白。
Objective To observe the effect of irbesartan and tripterygium glycosides on clinical symptoms, urine protein, serum albumin, serum creatinine and white blood cells in patients with diabetic nephropathy. Methods 64 patients were randomly divided into observation group and treatment group, 32 cases in each group. Both groups are suitable for treatment of diabetes plus Irbesartan treatment group, on the basis of the observation group with tripterygium glycosides tablets. To 30d for a course of treatment, once every 3 courses, observed changes in both groups. Results The observation group had higher Upro, Scr, ALB and WBC before treatment than those before treatment, and the difference was statistically significant (P <0.01). Upro, Scr, ALB and WBC in observation group and treatment group were significantly improved, the differences were Statistical significance (P <0.01). Conclusion Tripterygium glycosides tablets with irbesartan treatment of diabetic nephrosis significant effect, can significantly reduce proteinuria, relieve symptoms and improve serum albumin.