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目的比较拮抗剂周期中孕酮两种给药途径黄体支持对辅助生殖结局的影响,探讨更合理的黄体支持方案。方法 2011年4月～2012年4月在我院生殖中心采用拮抗剂周期进行辅助生殖治疗的不孕患者共352例,根据黄体支持的孕酮给药途径分为阴道给药组和肌肉注射组,比较两组黄体支持对辅助生殖结局的影响。结果阴道给药组临床妊娠率为46.94%,种植率为23.25%,流产率为8.7%;肌肉注射组临床妊娠率为35.58%,种植率为19.4%,流产率为10.2%,两组间各率均未见统计学差异。结论阴道用孕酮用于拮抗剂周期黄体支持的效果良好、不良反应少,可以代替肌注孕酮在临床中进行广泛应用。
Objective To compare the effects of two routes of administration of progesterone on the assisted reproductive outcome in the cycle of antagonists, and to explore a more reasonable luteal support plan. Methods From April 2011 to April 2012, 352 infertile patients who received assisted reproductive cycles in the Reproductive Center of our hospital for assisted reproductive therapy were divided into vaginal administration group and intramuscular injection group according to the progesterone-administered route of luteal support The effects of two groups of corpus luteum support on assisted reproductive outcome were compared. Results The clinical pregnancy rate was 46.94%, the implantation rate was 23.25% and the abortion rate was 8.7% in the vaginal administration group. The clinical pregnancy rate in the intramuscular injection group was 35.58%, the implantation rate was 19.4% and the abortion rate was 10.2% No statistical differences were observed. Conclusions Vaginal progesterone is a good substitute for cyclophosphamide for the antagonist and has few adverse reactions. It can be widely used in clinic instead of intramuscular injection of progesterone.