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甲胎蛋白(AFP)的检测对原发性肝癌的诊断具,有相对特异性,但对AFP低浓度或亚临床肝癌不易早期发现,阳性率相对较低。如对原发性肝癌患者或疑诊患者,同时进行AFP、血清铁蛋白(SF)联检,阳性率明显增高,现将结果报告如下。 材料和方法 一、病例来源:81例原发性肝癌患者(男66,女15)为我院住院和门诊病人,均经临床、实验室、B型超声,部分病例经CT及手术病理诊断证实,符合原发性肝癌诊断。年龄36～79岁,平均54.2岁。 二、方法:81例患者均上午8～10点采空腹静脉血,及时分离血清置-20℃O冰箱贮存。AFP及SF试剂盒均为上海放射免疫分析技术研究所提供。测量仪器为西安二六二厂生产的FJ-2003/50A型全自动γ计数器。 结果 将AFP测定值≤20ng/ml定为阴性,20ng/ml以上为阳性。SF男性>240ng/ml为阳性,女性>132ng/ml为阳性。AFP阴性与临床不符患者的SF多为阳性,见表10 讨论 本组原发性肝癌患者AFP总阳性率75.3％,这样较易造成临床漏诊或延误诊断,而SF阳性率高达80％以上,说明SF对原发性肝癌确有一定的诊断作用,其中AFP阴性的原发性肝癌患者的SF阳性率明显高于AFP阳性率(p<0.05)。
The detection of alpha-fetoprotein (AFP) has a relatively specific specificity for the diagnosis of primary liver cancer, but low concentrations of AFP or subclinical liver cancer are not easily detected early, and the positive rate is relatively low. For patients with primary liver cancer or suspected patients, the positive rate of combined AFP and serum ferritin (SF) was significantly increased. The results are reported below. Materials and methods 1. Case origin: 81 patients with primary liver cancer (66 males and 15 females) were hospitalized and outpatients in our hospital. All patients were clinically, laboratoryly, and B-mode ultrasound. Some cases were confirmed by CT and pathological diagnosis. , in line with the diagnosis of primary liver cancer. Age 36 to 79 years old, average 54.2 years old. Second, the method: 81 patients were 8 to 10 am morning fasting venous blood, timely separation of serum storage -20 ° CO refrigerator storage. AFP and SF kits are provided by Shanghai Institute of Radioimmunoassay. The measuring instrument is an FJ-2003/50A automatic gamma counter produced by Xi’an 262 Factory. RESULTS: The AFP measurement was ≤20 ng/ml negative, and 20 ng/ml or more positive. SF males were positive at >240 ng/ml and females were positive at >132 ng/ml. AFP-negative and clinical inconsistent patients with SF mostly positive, see Table 10 Discussion This group of patients with primary liver cancer AFP total positive rate of 75.3%, this is more likely to cause clinical missed diagnosis or delayed diagnosis, and SF positive rate as high as 80% or more, indicating SF has a certain diagnostic effect on primary liver cancer, among which the positive rate of SF in patients with AFP negative primary liver cancer is significantly higher than that of AFP (p<0.05).