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目的：探讨舒血宁联合依达拉奉对急性脑梗塞患者血浆内皮素及血清炎症因子的影响。方法将67例急性脑梗死患者按照随机数字表法分为观察组33例和对照组34例，两组均给予急性脑梗死常规治疗，观察组同时予以舒血宁注射液联合依达拉奉治疗，观察14 d。依据脑卒中患者临床神经功能缺损程度评分标准判定临床疗效，治疗前后检测两组患者血浆内皮素及血清炎症因子水平的变化。结果治疗后两组血浆内皮素及血清炎症因子各项指标水平均较治疗前显著下降（P＜0．01），且观察组显著低于对照组（P＜0．01）；观察组总有效率为93．9％，对照组为73．5％，观察组显著高于对照组（χ2＝5．08，P＜0．05）。结论对急性脑梗死患者在常规治疗的同时予以舒血宁联合依达拉奉治疗具有协同增效作用，能有效调节患者的血浆内皮素和血清炎症因子水平，减轻神经细胞损伤和机体炎症反应程度。“,”Objective To explore influences of shuxuening injection combined with edaravone on endothe‐lin and serum inflammatory factors of patients with acute cerebral infarction (ACI) .Methods Sixty‐seven ACI patients were divided into observation (n=33) and control group (n=34) according to random num‐ber table ,both groups received conventional therapy for ACI ,and observation was plus shuxuening injec‐tion and edaravone for 14 days .Efficacies were assessed according to MESSS ,changes of plasma endothe‐lin and serum inflammatory factors levels detected before and after treatment .Results All indexes levels of plasma endothelin and serum inflammatory factors of both groups lowered more significantly after treat‐ment compared with pretreatment (P<0 .01) ,those were significantly lower in observation than in control group (P<0 .01);total effective rate was respectively 93 .9% in observation and 73 .5% in control group , the former significantly higher than the latter (χ2 =5 .08 ,P< 0 .05) .Conclusion Shuxuening combined with edaravone in addition to conventional therapy for ACI has a synergism ,could effectively regulate pa‐tients’ plasma endothelin and serum inflammatory factors levels ,and lighten nerve cells injury and organ‐ism inflammatory reaction degrees .