本文共分三部分,急性毒性实验,亚急性毒性实验,安全系数测定。急性毒性试验采用简化机率法,小鼠尾静脉注射江浙蝮蛇抗栓酶(Svate),测定其LD_(50)为2.06±0.118(u/Kg)。用大鼠、兔进行亚急性毒性实验,给药三周,在高于常用量10倍时,肝肾功能未见明显改变。其安全系数在100倍以上。 This article is divided into three parts, acute toxicity test, subacute toxicity test, safety factor determination. The acute toxicity test was conducted using the simplified chance method. The mouse tail vein was injected with Svate, and its LD_(50) was determined to be 2.06±0.118(u/Kg). Rats and rabbits were used for the subacute toxicity test. Three weeks after the administration, the liver and kidney function did not change significantly when it was 10 times higher than the usual dose. Its safety factor is more than 100 times.