目的　为了解ＨＳＳ介导化疗药物阿霉素（ＡＤＭ） 对人肝癌裸鼠移植瘤作用及其对ｃｍｅｔ 癌基因的影响。方法　裸鼠移植瘤腹腔内注射化疗药物及ＨＳＳ２ 周，病理学检查、免疫组化法检查ｃｍｅｔ 癌基因。结果　中剂量ＡＤＭ（０．２５ μｇ／ｇｂｗ）联合ＨＳＳ抑瘤率达７２％ （Ｐ＜０ ．０１） ，单用大剂量ＡＤＭ（０．５０ μｇ／ｇｂｗ）无明显作用（Ｐ＞ ０．０５） ，但不良反应明显，单用ＨＳＳ无抑瘤及刺激增生作用。裸鼠移植瘤组织表达ｃｍｅｔ 癌基因，ＨＳＳ单用组对ｃｍｅｔ 影响不大，中剂量联合组ｃｍｅｔ 表达明显。结论　ＨＳＳ介导中剂量ＡＤＭ 的抑瘤效用可能与影响ｃｍｅｔ 的表达有关。 Objective To understand the effect of HSS-mediated chemotherapy drug doxorubicin (ADM) on transplanted human hepatocellular carcinoma in nude mice and its effect on cmet oncogene. Methods nude mice transplanted with intraperitoneal injection of chemotherapeutic drugs and HSS for 2 weeks, pathological examination, immunohistochemistry for c-met oncogene. Results The inhibitory rate of medium-dose ADM (0.25 μg/gbw) combined with HSS was 72% (P<0.01), and the single-dose ADM (0.50 μg/gbw) had no significant effect (P> 0.05). ) However, adverse reactions were obvious. HSS alone had no anti-tumor effect and stimulated proliferation. The expression of cmet oncogene was observed in nude mice transplanted with xenografts. The HSS alone group had little effect on cmet, and the cmet expression was significant in the combined dose group. Conclusion The inhibitory effect of HSS on medium-dose ADM may be related to the effect of cmet expression.