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目的探讨神经元特异性烯醇化酶(neuron specific enolase,NSE)、S100B蛋白在婴儿痉挛症(in-fantile spasm,IS)患儿发作期和临床控制期脑脊液与血清中浓度的相关关系及临床意义。方法应用ELISA方法定量检测32例婴儿痉挛症患儿发作期与控制期脑脊液与血清中NSE、S100B蛋白浓度;28例同年龄组非神经系统疾病患儿设为对照组。结果婴儿痉挛症发作期患儿脑脊液与血清中NSE、S100B蛋白水平均显著高于临床控制期和对照组(P<0.01);S100B蛋白临床控制期脑脊液与血清中的浓度高于对照组(P<0.05),而同期NSE水平与对照组无显著性差异(P>0.05)。各组脑脊液与血清含量密切相关(P<0.01)。结论痉挛发作可导致脑损伤,NSE、S100B蛋白水平各自在脑脊液和血清中的浓度密切相关,检测血清NSE和S100B蛋白是一种简便、有效的判断脑损伤的方法。
Objective To investigate the relationship between neuron specific enolase (NSE) and S100B protein in cerebrospinal fluid (CSF) and serum in the onset and clinical control of infantile spasm (IS) and its clinical significance . Methods Serum levels of NSE and S100B in cerebrospinal fluid (CSF) and serum were determined by ELISA in 32 infants with infantile spasms. 28 children with non-neurological diseases in the same age group were enrolled as control group. Results The levels of NSE and S100B in cerebrospinal fluid and serum of infants with infantile spasms were significantly higher than those in clinical controls and controls (P <0.01). The concentrations of S100B protein in cerebrospinal fluid and serum during clinical control were higher than those in control group (P <0.05), while there was no significant difference between the NSE levels and the control group (P> 0.05). Cerebrospinal fluid of each group was closely related to serum content (P <0.01). Conclusion The onset of spasm can lead to brain injury. The concentration of NSE and S100B protein in cerebrospinal fluid and serum are closely related. Detecting serum NSE and S100B protein is a simple and effective method to judge brain injury.