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目的：了解长期接触低浓度氯气对上呼吸道粘膜的影响程度。方法∶观察３１名新入厂工人在接触平均０．０９ｍｇ／ｍ３浓度的氯气前后一年的鼻粘膜功能、超微结构的变化。结果：接触后鼻纤毛运动功能及鼻腺体分泌功能较接触前降低，但两种功能无显著相关性。光镜下，见腺体增多，伴炎症细胞浸润；电镜下，见接触后７６％～７９％柱状细胞上皮纤毛脱落、破坏，３３％～４７％显示鳞状上皮化生，９２％线粒体之双膜结构不完整，嵴减少、消失或髓样变，１例胶原纤维进入上皮细胞间隙。结论：线粒体改变为低浓度氯气对人鼻粘膜影响的敏感性亚细胞标志。
Objective: To understand the effect of long-term exposure to low concentrations of chlorine on the upper respiratory tract mucosa. Methods: The changes of nasal mucosa function and ultrastructure of 31 new factory workers exposed to chlorine gas with an average concentration of 0.09 mg / m3 were observed. RESULTS: Nasal ciliary function and nasal gland secretion decreased after contact, but no significant correlation was found between the two functions. Light microscopy, see the gland increased, with infiltration of inflammatory cells; electron microscopy, see the contact 76% ~ 79% columnar epithelial cilia shedding, destruction, 33% to 47% showed squamous metaplasia, 92% of mitochondrial double Membrane structure is incomplete, crest reduction, disappearance or medullary change, 1 case of collagen fibers into the epithelial cell gap. CONCLUSIONS: Mitochondrial changes to a sensitive subcellular marker of the effect of low concentrations of chlorine on human nasal mucosa.