尖锐湿疣(CA)是感染人乳头瘤病毒(HPV)引起的一种常见的性传播疾病(STD)。鬼臼毒素能抑制细胞增殖,以鬼臼毒素为主药的制剂在临床已应用多年,疗效肯定。当前应用于临床的鬼臼毒素剂型主要是软膏、酊剂、凝胶剂等,而纳米载药新剂型,如脂质体、微乳凝胶、固体脂质纳米粒、醇质体、纳米脂质载体等仍处于实验室研究阶段,但其具有对皮肤、黏膜靶向性好、刺激性小、系统吸收少等优点。 Condyloma acuminatum (CA) is a common sexually transmitted disease (STD) caused by infection with human papillomavirus (HPV). Podophyllotoxin can inhibit cell proliferation, with podophyllotoxin-based formulations of the drug has been used for many years in clinical, curative effect. Currently used in clinical podophyllotoxin formulations are mainly ointment, tincture, gel, etc., and new drug-loaded nano-dosage forms, such as liposomes, microemulsion gel, solid lipid nanoparticles, alcohol, Carriers and other laboratory research is still in the stage, but it has good skin, mucosal targeting, irritation, the system less absorption and so on.