关节炎、类风湿关节炎和红斑狼疮等是一类常见、多发性的胶原组织疾病。对这类炎症,早期的糖皮质激素甾体抗炎药(SAID)虽有较好疗效,但长期应用可产生依赖性,且有易引起肾上腺皮质功能衰退等副作用。五十年代后期便转向非甾体抗炎药(NSAID)的研究,试图获得疗效确实、副作用小且宜长期服用的药物。目前临床应用的 NSAID 如阿斯匹林、消炎痛和布洛芬等,都有不同程度的中枢和胃肠道副作用,有时使患者不能忍受而被迫停药。因此,国内外 Arthritis, rheumatoid arthritis and lupus are a common class of multiple collagen disease. For this type of inflammation, the early glucocorticoid steroid anti-inflammatory drugs (SAID), although a good effect, but long-term use can produce dependence, and may lead to adverse effects such as adrenal cortex decline. In the late 1950s, the study turned to non-steroidal anti-inflammatory drugs (NSAIDs) in an effort to obtain drugs with proven efficacy, low side effects and long-term use. The current clinical application of NSAID such as aspirin, indomethacin and ibuprofen, have varying degrees of central and gastrointestinal side effects, and sometimes patients can not tolerate forced withdrawal. Therefore, at home and abroad