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目的:探讨力竭运动中大鼠苍白球内侧部对皮层的调控作用。方法:采用皮层脑电(ECoG)及局部场电(LFPs)同步记录技术,动态观察一次性力竭运动中大鼠皮层辅助运动区、苍白球内侧部神经元电活动变化规律。结果:运动开始阶段,大鼠能够自主跟随跑台进行运动,持续约43 min(43±11.8 min)后,大鼠自主运动能力明显降低,此时,皮层神经元功率谱重心频率显著降低(P<0.01),提示神经元兴奋性下降,而苍白球内侧部神经元功率谱重心频率显著升高(P<0.01),提示兴奋性增强;此时给予大鼠一定的外部刺激,大鼠仍可继续运动一段时间直至力竭,皮层神经元功率谱重心频率降至最低(P<0.01),而苍白球内侧部神经元功率谱重心频率达到最高(P<0.01)。力竭运动过程中,苍白球内侧部局部场电活动与皮层脑电活动呈相反变化趋势,且不同阶段两区域神经元在0~30Hz范围内均显著相干。结论:力竭运动过程中苍白球内侧部神经元兴奋性增强经丘脑中继后对皮层神经元产生去兴奋作用,是导致疲劳及运动能力下降的重要因素之一,提示苍白球内侧部-丘脑-皮层通路在运动疲劳产生过程中起重要调控作用。
OBJECTIVE: To investigate the regulation of the inner part of the globus pallidus on the cortex in exhaustive exercise. Methods: Cochlear EEG (ECoG) and local field recording (LFPs) simultaneous recording techniques were used to dynamically observe the changes of electrical activity in the cortical aortic motor area and the pallidolon in rats during one-time exhaustive exercise. Results: At the beginning of exercise, rats were able to follow the treadmill independently. After about 43 min (43 ± 11.8 min), the autonomic motor capacity of rats decreased significantly. At this time, the frequency of the center of gravity of cortical neurons decreased significantly (P <0.01), suggesting that the excitability of neurons decreased, whereas the frequency of the center of gravity of the neurons in the medial pallidus was significantly increased (P <0.01), suggesting that the excitability was enhanced. At this time, After continued exercise for a period of time until exhaustion, the frequency of the center of gravity of the cortical neurons was reduced to a minimum (P <0.01), while the frequency of the center of gravity of the medial pallidus neurons was the highest (P <0.01). During exhaustive exercise, the local field activity and the cortical EEG activity in the medial part of globus pallidus showed the opposite trend, and the neurons in the two regions were significantly coherent in the range of 0-30 Hz in different stages. CONCLUSIONS: Excessive excitability of the neurons in the globus pallidus during exhaustive exercise is one of the important factors that lead to the decrease of fatigue and motor ability after denervation of the hypothalamus, which indicates that the medial part of the globus pallidus - the thalamus - Cortical path plays an important role in the control of fatigue during exercise.