CXCR1和CXCR2属于G蛋白偶联受体家族成员,在血管内皮细胞上都有表达,因此被认为是调节血管内皮细胞化学趋化的主要功能性细胞趋化因子受体。血管内皮细胞能够感受力学刺激,发生一系列化学及形态学变化。我们前期的实验表明,血液流动产生的剪切力引起血管内皮细胞迁移显著增强, CXCR1 and CXCR2, members of the G-protein coupled receptor family, are expressed on vascular endothelial cells and are therefore considered to be major functional chemokine receptors that regulate chemotaxis of vascular endothelial cells. Vascular endothelial cells can feel mechanical stimuli, a series of chemical and morphological changes. Our previous experiments showed that shear force caused by blood flow caused a significant increase of vascular endothelial cell migration,