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自1975年开始以“欧洲共同体委员会环境研究规划”的名义,发起了一个对测试方法进行比较的协作性研究方案:用尽可能多的测试系统对化学物质的诱变作用进行估价。已对5种化合物的试验结果作了初步总结。这5种化合物是由“化学物质的遗传作用”联络组选出的。这5种化合物是甲磺酸甲酯(MMS)、二乙亚硝胺(DEN)、丝裂霉素(MC)、甲基苄肼(PC)、及阿特拉津(Atrazine AT,一种除莠剂,其有效成分为氯乙异丙嗪)。11个实验室提供了有关测试结果的资料。 MMS 为一单官能团强烷化剂,不需代谢
Since 1975, a collaborative research program has been launched to compare the test methods in the name of “Commission of the European Communities Environmental Research Program”: Use as many test systems as possible to assess the mutagenic effects of chemicals. The results of the five compounds have been tentatively summarized. The five compounds were selected from the liaison group on “Genetic Effects of Chemical Substances.” The five compounds were MMS, DEN, MC, PC, and Atrazine AT, Herbicides, the active ingredient is chlorpromazine). Eleven laboratories provided data on test results. MMS is a monofunctional strong alkylating agent, without metabolism