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目的:研究心理应激法诱导腹泻型肠易激综合征(IBS)大鼠模型内脏敏感性的变化,探讨肠易激综合征的发病机制及宁肠汤治疗肠易激综合征的机理。方法:SD雄性大鼠72只随机分为正常对照组、模型对照组、得舒特组、宁肠汤低、中、高剂量组6组,观察各组大鼠在不同容量下行直肠扩张AWR评分变化,观察宁肠汤的干预作用。结果:(1)各组大鼠的体重增长变化率差异无显著性意义(P>0.05);(2)慢性束缚应激+夹尾刺激诱导IBS大鼠内脏敏感性明显增高(P<0.01)。宁肠汤能降低IBS大鼠内脏敏感性的AwR评分(P<0.05～0.01),且有一定的量效关系,以高剂量组的效果最为明显。结论:宁心安神法对心理应激致IBS大鼠的内脏高敏感性有一定的调节作用。
Objective: To study the changes of visceral sensitivity in diarrhea-predominant irritable bowel syndrome (IBS) induced by psychological stress and to explore the pathogenesis of irritable bowel syndrome (IBS) and the mechanism of Ningchang Decoction in treating irritable bowel syndrome (IBS). Methods: Seventy-two male Sprague-Dawley rats were randomly divided into 6 groups: normal control group, model control group, D-shuet group and Ningchang decoction group. The rectal expansion and AWR score Changes, observe the intestine soup intervention. Results: (1) There was no significant difference in the rate of weight gain between the two groups (P> 0.05). (2) The visceral sensitivity of IBS rats was significantly increased after chronic restraint stress and tailgating stimulation (P <0.01) . Ningchang Decoction can reduce the visceral sensitivity of IBS rats AwR score (P <0.05 ~ 0.01), and there is a certain dose-effect relationship, the effect of high-dose group was the most obvious. Conclusion: Ningxin Anshen method has certain regulation effect on visceral hypersensitivity induced by psychological stress in IBS rats.