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脊椎动物的下颌骨发育涉及一系列信号分子和转录因子,颅神经嵴细胞(CNCC)的迁移、定位和调控是下颌骨发育的关键。转录因子家族在颅面组织发育中有着重要的作用,其表达在某种程度上决定了CNCC的特异性。此文就DLX基因家族、MSX基因家族、OTX基因家族、GSC基因家族、PITX基因家族、PAX基因家族、PRX基因家族、BARX基因家族和HAND基因家族以及其他调控下颌骨发育转录因子家族的研究进展作一综述。
Mandibular development in vertebrates involves a series of signaling molecules and transcription factors. Migration, localization and regulation of cranial neural crest cells (CNCCs) are key to mandibular development. The transcription factor family plays an important role in the development of craniofacial tissues, and its expression to some extent determines the specificity of CNCC. This review focuses on the research progress of the DLX gene family, the MSX gene family, the OTX gene family, the GSC gene family, the PITX gene family, the PAX gene family, the PRX gene family, the BARX gene family and the HAND gene family, and other regulatory transcription factor families of the mandible Make a review