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双组分系统(two component system,TCS)是结核分枝杆菌(Mycobacterium Tuberculosis,MTB)感应环境因素刺激,并作出相应反应,以适应环境变化的一种跨膜信号转导系统。MprAB作为MTB目前发现的11个完整的TCS之一,与MTB的持留性及调节应激反应等方面密切相关,本文就MTB MprAB TCS的研究进展进行了综述。
Two-component system (TCS) is a transmembrane signal transduction system stimulated by environmental factors of Mycobacterium tuberculosis (MTB) to respond to environmental factors and respond accordingly. As one of the 11 complete TCSs found in MTB, MprAB is closely related to the retention of MTB and the regulation of stress response. The progress of MTB MprAB TCS is reviewed in this paper.