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为比较研究不同表面电位的驻极体对环孢菌素A贴剂内模型药物的极化及其压电性影响,进一步探讨驻极体环孢菌素A贴剂内药物极化及释放机制,利用药剂学方法制备了空白贴剂和不同药物质量的环孢菌素A贴剂。利用电晕充电技术制备了不同表面电位的双裸面驻极体,将驻极体与环孢菌素A贴剂组合制备成驻极体贴剂。借助于等温表面电位衰减测量和准静态压电系数测量研究了驻极体对环孢菌素A贴剂压电性的影响。结果显示:驻极体环孢菌素A贴剂的内、外电场具有良好的稳定性;驻极体可引起环孢菌素A贴剂内模型药物的极化,药物的极化程度随驻极体表面电位的升高而增强、随驻极体作用时间的延长而衰减并逐步趋于稳定;环孢菌素A药物质量越高,则驻极体环孢菌素A贴剂的压电活性越低。可得结论:驻极体可引起环孢菌素A的极化,药物的极化与驻极体表面电位、驻极体作用时间、贴剂内模型的药物质量密切相关;驻极体产生的电场力与极化的药物分子相互作用,可实现模型药物在驻极体环孢菌素A贴剂内的可控释放。
In order to compare the polarization and piezoelectricity of cyclosporin A patch model electret with different surface potentials, we further investigate the mechanism of drug polarization and release mechanism of the electret cyclosporin A patch , The use of pharmacological methods of preparation of blank patches and cyclosporine A patch of different drug quality. The double-sided electrets with different surface potentials were prepared by corona charging technology. The electret patch was prepared by combining electret and cyclosporine A patch. The effect of electret on the piezoelectricity of cyclosporin A patch was studied by isothermal surface potential decay measurement and quasi-static piezoelectric coefficient measurement. The results showed that the internal and external electric fields of the cyclodextrin A patch had good stability. The electret induced the polarization of the model drug in the cyclosporin A patch. The polarization degree of the drug Polar body surface potential increases and enhances, with the extension of the electret role and decay and gradually stabilize; cyclosporin A drug quality is higher, then the electret cyclosporin A patch of piezoelectric The lower the activity. It can be concluded that the electret can cause the cyclosporin A polarization. The polarization of the drug is closely related to the surface potential of the electret, the duration of the electret, and the quality of the drug in the patch model. The electret-induced The electric field force interacts with polarized drug molecules to achieve controlled release of the model drug in the electret cyclosporin A patch.