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吩噻嗪类药物,尤其是氯丙嗪可影响体温调节中枢功能,引起药源性高热,甚至死亡,国内已有报道。现将我院住院患者中由复方氯丙嗪所致药源性高热23例,报道如下: 临床资料1977年8月4日,因一时药物短缺,将42例精神分裂症住院患者口服氯丙嗪1次等量改服复方氯丙嗪,23例出现骤然高热,其中3例死亡。一、性别与年龄:23例发热病人中男12例(52.2%),女11例(47.8%)。年龄9～52岁之间,平均年龄31.3岁。其中40岁以上发热
Phenothiazines, especially chlorpromazine, can affect the central function of thermoregulation, causing drug-induced fever and even death, which has been reported in China. Now in our hospital inpatients caused by compound chlorpromazine drug-induced fever in 23 cases, reported as follows: Clinical data On August 4, 1977, due to temporary drug shortage, 42 schizophrenic inpatients oral chlorpromazine 1 equivalent to change service compound chlorpromazine, 23 cases of sudden high fever, of which 3 died. First, sex and age: 23 cases of febrile patients, 12 males (52.2%) and 11 females (47.8%). Aged 9 to 52 years old, with an average age of 31.3 years. One of over 40 years old fever