It is found that the field of the combined mode of the probe wave and the phase conjugate wave in the process of non-degenerate four-wave mixing exhibits higher-order squeezing to all even orders. The higher-order squeezed parameter and squeezed limit due to the modulation frequency are investigated. The smaller the modulation frequency is, the stronger the degree of higher-order squeezing becomes. Furthermore, the higher-order uncertainty relations in the process of non-degenerate four-wave mixing are presented for the first time. The product of higher-order noise moments is related to even order number N and the length L of the medium.