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目的:调查高龄(≥80岁)女性服用维生素D和复方钙剂(简称复方钙剂)与骨密度、骨代谢标志物的关系。方法:对187例80~93(84±3)岁的高龄女性服用复方钙剂的情况进行调查,并进行骨密度和骨代谢标志物的检测,分析服用复方钙剂与骨密度、骨代谢标志物的关系。结果:服用复方钙剂的高龄女性骨质疏松患病率为41.51%,明显低于未服用复方钙剂的58.96%(P<0.05);与不服用复方钙剂的相比,服用复方钙剂的高龄女性血清Ⅰ型胶原羧基端肽β特殊序列、总Ⅰ型胶原氨基端前肽和N端骨钙素较低(均P<0.01)、25-羟基维生素D较高(P<0.001)。结论:服用复方钙剂可能有助于降低高龄女性的骨转换水平,提高其25-羟基维生素D水平,进而降低其骨质疏松的患病率。
OBJECTIVE: To investigate the relationship between vitamin D and compound calcium (referred to as compound calcium) and bone mineral density (BMD) and bone metabolic markers in elderly (≥80 years) women. Methods: A total of 187 elderly women aged 80-93 years (84 ± 3) were enrolled in this study. Bone mineral density (BMD) and markers of bone metabolism were measured. The effects of taking compound calcium on bone mineral density (BMD), bone metabolism Relationships. Results: The prevalence of osteoporosis in elderly women taking compound calcium was 41.51%, significantly lower than that of 58.96% without compound calcium (P <0.05). Compared with the group without compound calcium, (P <0.01). The 25-hydroxyvitamin D was higher (P <0.001) in the serum of patients with type Ⅰ collagen. Conclusion: Taking compound calcium may help reduce bone turnover in elderly women, increase their 25-hydroxy vitamin D levels, and thus reduce the prevalence of osteoporosis.