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目的评价炎症性肠病患者及正常对照者之间红细胞指数和血红蛋白的差异及其与疾病活动性的关系。方法队列研究271例炎症性肠病患者和正常对照者的红细胞指数和血红蛋白,分析红细胞指数和血红蛋白的改变和炎症活动性的关系。结果克罗恩病患者血红蛋白浓度(P<0.01)、平均红细胞容积(P<0.05)、平均红细胞血红蛋白含量(P<0.01)和平均红细胞血红蛋白浓度(P<0.01)显著低于正常对照组;溃疡性结肠炎患者血红蛋白浓度和平均红细胞血红蛋白浓度显著低于正常对照组(P<0.01)。相关分析表明,克罗恩病患者的血红蛋白浓度和克罗恩病活动指数(rs=-0.364,P=0.001)及红细胞沉降率(rs=-0.360,P=0.003)呈显著负相关;溃疡性结肠炎患者的血红蛋白浓度和红细胞沉降率呈显著负相关(rs=-0.565,P<0.001)。结论炎症性肠病患者的红细胞指数和血红蛋白发生变化,其中血红蛋白浓度的变化和疾病的活动性呈负性相关。
Objective To evaluate the difference of erythrocyte index and hemoglobin between patients with inflammatory bowel disease and normal controls and its relationship with disease activity. Methods A cohort of 271 infants with inflammatory bowel disease and normal controls was recruited to study the relationship between red blood cell index and hemoglobin, red blood cell index, hemoglobin change and inflammatory activity. Results The hemoglobin concentration (P <0.01), mean corpuscular volume (P <0.05), average erythrocyte hemoglobin content (P <0.01) and average hemoglobin hemoglobin concentration (P0.01) in Crohn’s disease patients were significantly lower than those in the control group The hemoglobin concentration and the mean erythrocyte hemoglobin concentration in patients with colitis were significantly lower than those in the normal control group (P <0.01). Correlation analysis showed that the hemoglobin concentration of Crohn’s disease patients was significantly negatively correlated with Crohn’s disease activity index (rs = -0.364, P = 0.001) and erythrocyte sedimentation rate (rs = -0.360, P = 0.003) There was a significant negative correlation between hemoglobin concentration and erythrocyte sedimentation rate in patients with colitis (rs = -0.565, P <0.001). Conclusion The red blood cell index and hemoglobin of patients with inflammatory bowel disease are changed. The change of hemoglobin concentration is negatively correlated with the activity of the disease.