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急性淋巴细胞白血病(ALL)的疗效日趋提高,详尽研究本病及其治疗的远期疗效十分必要。本文对照研究急性淋巴细胞白血病患儿行预防性头颅照射与未行预防性头颅照射对生长发育的影响。材料与方法急性淋巴细胞白血病患儿39例,女20例,男19例,平均发病年龄3.8岁(1.1～7.2岁),根据预防中枢神经系统病变的方法不同分为两组:头颅照射组,28例,平均发病年龄3.9岁(1.1～7.2岁),头颅照射量为24Gy;非头颅照射组,11例,平均发病年龄3.6岁(1.1～5.9岁),给予氨甲喋呤静注(500mg/m~2)和甲酰四氢叶酸治疗。两组均接受过氨甲喋呤鞘内注射。其他治疗如诱导治疗期间用强的松龙、阿霉素,长春新碱,维持治疗期间用6-巯基嘌
Acute lymphoblastic leukemia (ALL) the efficacy of increasingly improved, a detailed study of the disease and its long-term efficacy of treatment is necessary. In this paper, the control study of acute lymphoblastic leukemia in children with prophylactic head irradiation and non-preventive head irradiation on growth and development. Materials and Methods 39 cases of acute lymphoblastic leukemia in children, 20 cases, 19 males, average age of 3.8 years (1.1 to 7.2 years), according to the prevention of central nervous system disease is divided into two groups: the head irradiation group, (N = 28). The average age of onset was 3.9 years (ranged from 1.1 to 7.2 years), and the head irradiation was 24 Gy. In the non-cranial irradiation group, 11 patients (mean age ranged from 3.6 to 1.1 years) were given intravenous methotrexate (500 mg / 2) and leucovorin treatment. Both groups received methotrexate intrathecal injection. Other treatments such as prednisolone, doxorubicin, vincristine during induction therapy, maintenance with 6-mercaptopurine