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目的了解长沙市健康人群麻疹抗体水平和人群免疫状况,为有效地实施麻疹预防措施和控制策略提供科学依据。方法 2007年对2～39岁健康人群共847人采用酶联免疫吸附试验(ELISA)法进行麻疹IgG抗体水平检测。结果麻疹抗体阳性率为91.5%,保护率42.38%,几何平均滴度(GMT)为1:409.61。不同区(县)麻疹抗体阳性率之间差异有统计学意义;男性与女性麻疹抗体阳性率之间差异无统计学意义;不同区(县)、不同年龄组保护率和几何平均滴度(GMT)之间差异有统计学意义。结论加强对个别区县麻疹疫苗接种工作的督查,在保证常规免疫覆盖率的基础上,提高冷链运转和基层接种质量,采取局部强化免疫,针对部分中学生进行麻疹疫苗的复种,减少麻疹散发病例和学校的暴发疫情,也可维持人群有较高的抗体水平。
Objective To understand the level of measles antibody and immune status in healthy population in Changsha City, and provide a scientific basis for the effective implementation of measles prevention and control strategies. Methods A total of 847 healthy people aged 2 ~ 39 years old were enrolled in this study. The level of measles IgG was detected by enzyme linked immunosorbent assay (ELISA). Results The positive rate of measles antibody was 91.5%, the protection rate was 42.38%, and the geometric mean titer (GMT) was 1: 409.61. The positive rate of measles antibody in different districts (counties) was statistically different. There was no significant difference between the positive rates of measles antibody in males and females. The protection rates and geometric mean titers (GMTs) in different districts and counties ) Between the difference was statistically significant. Conclusion The supervision of measles vaccination work in individual districts and counties was strengthened. On the basis of ensuring routine immunization coverage, cold chain operation and grass-roots vaccination quality were improved. Local intensive immunization was adopted. Some secondary school students were vaccinated for multiple measles vaccine to reduce the spread of measles Cases and outbreaks in schools can also sustain the population with higher antibody levels.