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目的探讨T2DM患者血清脑源性神经营养因子(BDNF)与APN、瘦素(LP)、胰岛素抵抗指数(HOMA-IR)和ISI的相关性。方法选取T2DM组102例和健康对照(NC)组97名,将T2DM组进一步分为体重正常(N-OB)亚组53例和超重(OB)亚组49例。采用RT-PCR检测BDNF表达水平。对T2DM组BDNF表达水平的相关因素行Pearson相关性及多因素线性回归分析。结果 OB亚组BMI、TG、APN、LP和BDNF较N-OB亚组、NC组低(P<0.05或P<0.01)。多因素线性回归分析显示,仅LP进入回归方程。结论 T2DM患者BDNF表达水平降低,与LP呈正相关。
Objective To investigate the correlation between serum brain-derived neurotrophic factor (BDNF) and APN, leptin (LP), insulin resistance index (HOMA-IR) and ISI in T2DM patients. Methods Totally 102 T2DM patients and 97 healthy controls (NC) patients were selected. The T2DM patients were further divided into 53 cases of normal weight (N-OB) and 49 cases of overweight (OB). BDNF expression level was detected by RT-PCR. Pearson correlation and multivariate linear regression analysis were used to analyze the correlation of BDNF expression in T2DM group. Results The BMI, TG, APN, LP and BDNF in OB subgroup were lower than those in N-OB subgroup and NC subgroup (P <0.05 or P <0.01). Multivariate linear regression analysis showed that only LP entered the regression equation. Conclusion The expression of BDNF in T2DM patients is lower than that in LP patients.