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棉酚抗生育作用的机理国内外已有不少研究报导。国内王振刚等曾观察到棉酚对大鼠血浆 cAMP(环一磷酸腺苷)和 cGMP(环一磷酸乌苷)没有影响;而睾丸组织 cAMP 含量增加。为此,我们采用大剂量醋酸棉酚和较长时间给药对大鼠睾丸组织 cAMP 含量进行研究。
The mechanism of anti-fertility effect of gossypol has been studied and reported at home and abroad. Domestic Wang Zhengang et al. observed that gossypol had no effect on plasma cAMP (cyclic adenosine monophosphate) and cGMP (cyclic guanosine monophosphate) levels in rats; whereas cAMP content in testis tissue increased. To this end, we used high-dose gossypol acetate and a longer period of administration to study the cAMP content of rat testicular tissue.