论文部分内容阅读
目的:评估粉尘螨滴剂舌下特异性免疫治疗(sublingual immunotherapy,SLIT)对小年龄及多重过敏的变应性鼻炎患者的疗效及安全性。方法:回顾分析130例接受粉尘螨滴剂SLIT治疗2年且随访资料完整的变应性鼻炎(allergic rhinitis,AR)患者资料。根据皮肤点刺试验或血清特异性过敏原检测,按照是否单纯尘螨(粉尘螨或/和屋尘螨)过敏分为单一过敏组及多重过敏组,按照年龄分为低年龄组(<5岁)、高年龄组(≥5岁),按照患者所在地区分为城市组、农村组,通过不同时点(治疗前,治疗后第3、6、12、18、24个月)鼻炎症状评分(total nasal symptoms score,TNSS)对疗效进行评价。结果:130例给予舌下含服脱敏治疗的变应性鼻炎中,滴药0.5 h内出现不良反应的有9例,发生率为6.92%(9/130),治疗前、治疗后第3、6个月,单一过敏组TNSS均明显低于多重过敏组(Z=-5.86、6.692、-5.803,P<0.05),治疗后第12个月开始,两组TNSS比较,差异均无统计学意义(Z=-0.804、-1.030、-0.455,P>0.05)。治疗前、治疗后第3个月,低年龄组TNSS均明显高于高年龄组(Z=-3.225、-2.955,P<0.05),治疗后第6个月开始,两组TNSS比较差异均无统计学意义(Z=-0.159、-0.100、-0.498、-1.493,P>0.05)。农村组和城市组治疗前后TNSS比较,差异均无统计学意义(P>0.05)。结论:粉尘螨滴剂舌下脱敏治疗对小年龄及多重过敏的变应性鼻炎患者有良好的疗效和安全性。
PURPOSE: To evaluate the efficacy and safety of sublingual immunotherapy (SLIT) with dust mite drops on patients with allergic rhinitis of younger age and multiple allergies. Methods: The data of 130 patients with allergic rhinitis (AR) who received SLIT for 2 years and were followed up were retrospectively analyzed. According to the skin prick test or serum-specific allergen test, the subjects were divided into single allergy group and multiple allergy group according to whether the allergy of dust mite (dust mite and / or house dust mite) was simple, and were divided into the lower age group (<5 years old ), And high age group (≥5 years old) were divided into urban group and rural group according to the patient’s location. The rhinitis symptom score (total score before treatment, 3,6,12,18,24 months after treatment) nasal symptoms score, TNSS). Results: In the 130 cases of allergic rhinitis treated with sublingual desensitization, there were 9 cases with adverse reaction within 0.5 h after dropping drug, the incidence rate was 6.92% (9/130). Before treatment and after treatment, , 6 months, TNSS in single allergy group were significantly lower than those in multiple allergy group (Z = -5.86,6.692, -5.803, P <0.05). At the 12th month after treatment, there was no significant difference in TNSS between the two groups Significance (Z = -0.804, -1.030, -0.455, P> 0.05). TNSS in the low-age group were significantly higher than those in the high-age group (Z = -3.225, -2.955, P <0.05) before treatment, the third month after treatment, and the sixth month after the treatment. There was no significant difference in TNSS between the two groups Statistical significance (Z = -0.159, -0.100, -0.498, -1.493, P> 0.05). There was no significant difference in TNSS between rural group and urban group before and after treatment (P> 0.05). Conclusion: Dust mites drops sublingual desensitization treatment of small age and multiple allergic rhinitis patients have good efficacy and safety.