目的：研究隐丹参酮（ＣＴ）及其代谢物丹参酮ＩＡ（ＴＳ）在猪体内的药代动力学。方法：实验猪５头，单剂量（１０ｍｇ·ｋｇ－１）ｉｖ隐丹参酮后，采用反相ＨＰＬＣ法检测ＣＴ及ＴＳ的血浆浓度。以二苄基为内标，流动相为甲醇—水（８５∶１５），检测波长２５４ｎｍ。结果：ＣＴ血药时程符合二室开放模型。ｉｍ与ｐｏ给药后，ＣＴ和ＴＳ的血药浓度很低。少量原药及其代谢产物在胆汁中随着给药时间的延长逐渐增多。不同途径给药后（ｉｖ及ｐｏ），隐丹参酮及丹参酮ＩＡ在尿中的排泄量占给药剂量的比例很小。结论：猪ＣＴ及ＴＳ药代动力学数据为动物临床用药提供有价值的理论依据 Objective: To study the pharmacokinetics of cryptotanshinone (CT) and its metabolite tanshinone IA (TS) in pigs. Methods: Five experimental pigs were treated with iv cryptotanshinone at a single dose (10 mg · kg -1). The plasma concentrations of CT and TS were determined by reverse phase HPLC. Dibenzyl as internal standard, the mobile phase was methanol - water (85:15), detection wavelength 254nm. Results: CT blood time course in line with two-compartment open model. Plasma concentrations of CT and TS are low after im and po administration. A small amount of the original drug and its metabolites gradually increase in the bile with the dosing time. Different routes of administration (iv and po), cryptotanshinone and tanshinone IA in the urinary excretion accounted for a small proportion of the dose. Conclusion: The porcine CT and TS pharmacokinetic data provide valuable theoretical basis for the clinical use of animals