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本文研究了喂饲醋酸棉酚(每只10mg/日)17周对正常和动脉粥样硬化造型家兔的主动脉病变和血清总补体的影响,并观察了在喂饲过程中血脂和某些脂酶的活性变化。结果表明,醋酸棉酚无促进或加重主动脉粥样病变的作用;对血清高密度脂蛋白胆固醇水平及肝素后血浆脂蛋白脂酶和肝脂酶活性亦无明显影响。血清总补体水平在给药组和对照组间无显著性差异(P>0.05)。血清胆固醇和甘油三酯在喂饲醋酸棉酚期间有些改变,但尚不能确定是否为药物的作用。
This study investigated the effects of gossypol acetate (10 mg / day) for 17 weeks on aortic lesions and total serum complement in normal and atherosclerotic rabbits and observed the effects of lipid and some Lipase activity changes. The results showed that gossypol acetate did not promote or aggravate the role of aortic atherosclerosis; serum high-density lipoprotein cholesterol levels and heparin plasma lipoprotein lipase and hepatic lipase activity also had no significant effect. There was no significant difference in the level of serum total complement between the administration group and the control group (P> 0.05). Serum cholesterol and triglycerides were somewhat altered during the gossypol acetate infusion, but it was not yet clear whether this was a drug effect.