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[目的]调查患有或不患有氯痤疮的三氯苯酚(trichlorophenol,TCP)或五氯苯酚(pentachlorophenol,PCP)接触工人血清的二恶英水平,并观察患氯痤疮工人的特征.[方法]收集26名PCP工人、12名TCP工人和36名没有PCP和TCP暴露史工人的血样,并测定二恶英含量.氯痤疮的确定根据工厂医疗记录.[结果]PCP工人中,患氯痤疮与未患氯痤疮的工人相比具有更高毒性当量(根据世界卫生组织)的2378-TCDD,12378-PeCDD,123678-H6CDD,123789-H6CDD和123678-H6CDF水平.而在TCP工人中,虽然曾患有氯痤疮的工人血清中2378-TCDD水平较高,但与未患有氯痤疮者的血清水平上并无明显差异.氯痤疮的公认危险因素有首次暴露年龄较小和距第一次暴露的时间较长等,但仅在接触TPC工人中得到证实.PCP工人患氯痤疮和诊断前较长的接触时间相关.[结论1氨痤疮是二恶英高暴露的良好指标.TCP和PCP接触工人的血清二恶英同系物具有明显不同的特点.“,”[Objective]To determine if serum dioxin levels are higher among trichlorophenol (TCP) or pentachlorophenol (PCP) workers with and without chloracne and to examine characteristics of workers with chloracne.[Methods]We collected blood from 26 PCP workers,12 TCP workers,and 36 workers with no PCP or TCP exposure and measured dioxin levels.Chloracne was determined by examining plant medical records.[Results]We observed higher serum levels of the toxic equivalency (according to the World Health Organization) based on 2378-TCDD for 12378-PeCDD,123678-H6CDD,123789-H6CDD,and 123678-H6CDF among the PCP workers with chloracne compared to the PCP workers with no chloracne.There were no significant differences in serum levels for the TCP workers by chloracne status,although the 2378-TCDD levels were higher among the participants who previously had chloraene (43.6 ppt vs.16.4 ppt).The putative risk factors for chloraene of younger age at first exposure and more years since first exposure were observed in the TCP workers but not the PCP workers.Chloracne in the PCP workers was associated with longer duration of exposure prior to the diagnosis.[Conclusion]Chloracne is a good indicator for high dioxin exposures,and TCP and PCP workers have distinctively different serum profiles of dioxin congeners.