作者应用灭活多价完整病毒疫苗、亚单位疫苗和裂解病毒疫苗,在5～9岁及9～12岁儿童中,进行了反应原性及免疫原性的比较。 5～9岁儿童皮下接种完整病毒疫苗或裂解病毒疫苗0.25ml或亚单位疫苗0.5ml,9～12岁儿童接种完整病毒疫苗或裂解病毒疫苗0.5ml,1个月后,每个志愿者再接种同种疫苗。每次接种后24和48小时,观察反应并测量体温。接种前和第2次接种后4周采取 Inactivation of multivalent whole virus vaccine, subunit vaccine and split virus vaccine was used to compare the reactivity and immunogenicity of children aged 5 to 9 and 9 to 12 years. Children aged 5 to 9 years were inoculated with either a complete virus vaccine or a split virus vaccine 0.25 ml or a subunit vaccine 0.5 ml, and children aged 9 to 12 years were vaccinated with a complete virus vaccine or split virus vaccine 0.5 ml. One month later, each volunteer was re-vaccinated The same vaccine. At 24 and 48 hours after each inoculation, the reaction was observed and body temperature measured. Before vaccination and 2 weeks after the second inoculation