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双氢埃托啡(DHE)是东罂粟碱类高效镇痛剂之一。本文观察了DHE舌下含片对129例术后患者的镇痛效果。DHE在不同剂量的镇痛有效率:20μg为80％,40μg为95％,50μg为100％。7例患者无效。20、40和50μg剂量生效时间分别为14、16和16min,持续有效时间分别为173、221和262min。40～80μg有7例产生副作用,出现呼吸减慢(11次/min)、头晕、恶心、呕吐,其中1例还出现面色苍白、出汗、血压下降。这些副作用在稍加休息后均可恢复。观察结果表明,DHE舌下含片顿服30～40μg对手术后患者是适用的。
Dihydroetorphine (DHE) is one of the highly effective oriental papaverine analgesics. This article investigates the analgesic effect of DHE sublingual tablets on 129 postoperative patients. Efficacy of DHE at different doses of analgesia was 80% for 20μg, 95% for 40μg and 100% for 50μg. Seven patients were ineffective. The effective time of 20, 40 and 50μg dose were 14, 16 and 16min respectively, and the sustained effective time was 173, 221 and 262min respectively. There were 7 cases of 40 ~ 80μg side effects, slow breathing (11 beats / min), dizziness, nausea and vomiting. One of them also appeared pale, sweating and blood pressure decreased. These side effects recover after a little rest. Observations show that, DHE sublingual buccal tablets serving 30 ~ 40μg is suitable for postoperative patients.